Cell3™ Target: Actionable Mutation Panel (EGFR)

Detect actionable mutations in the EGFR pathway in primary tumor or liquid biopsy. Fast

Target enrichment of the key oncogenes in the EGFR pathway. Giving you a quick and sensitive method for monitoring even the lowest frequency variants

Sensitive. Accurate. Affordable.

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Clinically relevant content

A highly focused panel covering the actionable mutations in key oncogenes in the EGFR pathway.

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Primary Tumor or Liquid biopsy

Developed for and validated on ctDNA as well as gDNA and FFPE giving you the option to profile primary tumors or liquid biopsies and matched samples.

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Confidently Call Low Frequency Variants

Cell3™ Target error suppression technology including unique molecular identifiers (UMIs), enables you to accurately call ultra-low frequency mutations down to 0.1% VAF.

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Fast and affordable

Using a focused panel simplifies analysis and reduces costs making this a fast and affordable method of profiling variants in the EGFR pathway.

Sensitive enough for liquid biopsy

Liquid biopsy offers a non-invasive method of detecting cancer early or monitoring cancer post chemotherapy or surgery, but it requires extremely sensitive analysis due to the small amounts of cell free (cfDNA) and even smaller amounts of circulating tumor (ctDNA) present. The error suppression technology of Nonacus’ Cell3™ Target libraries includes unique molecular indexes (UMIs) and unique dual indexes (UDIs) for removal of both PCR and sequencing errors and index hopping events. This ensures that the Actionable Mutation panel (EGFR) will enable you to confidently call mutations down to 0.1% VAF from as little as 10ng ctDNA input.

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Table 1. Gene content for Cell3TMTarget: Actionable Mutation Panel (EGFR)

Focused coverage

We know that a fast and affordable panel for profiling pathways like the EGFR pathway is important to you so the Cell3™ Target: Actionable Mutation panel (EGRF) only enriches for actionable mutations in the most relevant oncogenes. It offers a simple, fast and cost-effective tool to enable early cancer detection, treatment selection and patient monitoring in cancers like non-small lung cancer.

Maximise sequencing efficiency

By increasing the yield per sample, Nonacus Cell3™ Target library preparation solutions allow you to run more samples per flow cell increasing your efficiency and reducing your cost per sample.

Table 2. No. of samples per flow cell to achieve 100x mean depth of coverage based on 2 x 100bp library and maximum quoted sequencer output for Nonacus Cell3™ Target: Actionable Mutation panel (EGFR)

Product Resources

Detailed product information available to download.

For Research Use Only. Not for use in diagnostic procedures.

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