Oncology
A novel bead-capture nanopore sequencing method for large structural rearrangement detection in cancer | Fisher CL, et al | Journal of Molecular Diagnostics | Dec. 2022
Fisher CL, Dillon R, Anguita E, Morris-Rosendahl DJ, Awan AR. A novel bead-capture nanopore sequencing method for large structural rearrangement detection in cancer. The Journal of Molecular Diagnostics. 2022;24(12):1264-78. Nonacus products: Oncology Abstract Rapid, cost-effective genomic stratification of structural rearrangements in cancer is often of vital importance when determining treatment; existing diagnostic cytogenetic and molecular testing…
Read MoreAn association study of germline variants in bladder cancer-related genes with the prognosis of non-muscle invasive bladder cancer | Hof JP, et al | Bladder Cancer | Jan. 2023
Hof JP, Vermeulen SH, van der Heijden AG, Verhaegh GW, Dyrskjøt L, Catto JW, et al.An association study of germline variants in bladder cancer-related genes with the prognosis of non-muscle invasive bladder cancer. Bladder Cancer. 2023;9(1):59-71. Nonacus products: Oncology Background Various germline genetic variants are associated with the prognosis of non-muscle invasive bladder cancer (NMIBC).…
Read MoreAn internal pilot study of a novel rectal mucocellular sampling device to allow next-generation sequencing for colorectal disease | Humphrey HN, et al | Techniques in Coloproctology | 2023
Humphrey HN, Diodato A, Isner JC, Walker E, Lacy-Colson J, Nedjai B, et al. An internal pilot study of a novel rectal mucocellular sampling device to allow next-generation sequencing for colorectal disease. Techniques in Coloproctology. 2023;27(3):227-35. Nonacus products: Oncology Background The ORI-EGI-02 study was designed to test the hypothesis that rectal mucus collected using a…
Read MoreCoincidence of primary adrenocortical carcinoma and melanoma: three CASE reports | Ko YL, et al | BMC Endocrine Disorders | Jan. 2023
Ko YL, Kumar V, Lippert J, Diaz-Cano S, Skordilis K, Kimpel O, Coincidence of primary adrenocortical carcinoma and melanoma: three CASE reports. BMC Endocrine Disorders. 2023 Jan;23(1):4. Nonacus products: Custom panels Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a heterogeneous prognosis, while adrenal metastasis from other primary cancers, including melanoma, may…
Read MoreHighly sensitive and specific detection of bladder cancer via targeted ultra-deep sequencing of urinary DNA | Ward DG, et al | European Urology Oncology | Feb. 2023
Ward DG, Baxter L, Ott S, Gordon NS, Wang J, Patel P, et al Highly sensitive and specific detection of bladder cancer via targeted ultra-deep sequencing of urinary DNA. European Urology Oncology. 2023;6(1):67-75. Nonacus products: Oncology Abstract There is an unmet need for an accurate, validated, noninvasive test for diagnosing and monitoring bladder cancer (BC).…
Read MoreSensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours | Maher GJ, et al | NPJ Genomic Medicine | Apr. 2022
Maher GJ, Fisher RA, Kaur B, Aguiar X, Aravind P, Cedeno N, et al. Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours. NPJ Genomic Medicine. 2022;7(1):26. Nonacus Products: Oncology Abstract Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity,…
Read MoreApplications and analysis of targeted genomic sequencing in cancer studies | Bewicke-Copley F, et al | Computational and Structural Biotechnology Journal | Jan. 2019
Bewicke-Copley F, Kumar EA, Palladino G, Korfi K, Wang J. Applications and analysis of targeted genomic sequencing in cancer studies. Computational and structural biotechnology journal. 2019;17:1348-59. Nonacus Products: Germline Abstract Next Generation Sequencing has dramatically improved the flexibility and outcomes of cancer research and clinical trials, providing highly sensitive and accurate high-throughput platforms for large-scale…
Read MoreCirculating cell-free DNA captures the intratumor heterogeneity in multinodular hepatocellular carcinoma | Coto-Llerena M, et al | JCO Precision Oncology | Mar. 2022
Coto-Llerena M, Benjak A, Gallon J, Meier MA, Boldanova T, Terracciano LM, et al. Circulating cell-free DNA captures the intratumor heterogeneity in multinodular hepatocellular carcinoma. JCO precision oncology. 2022;;6:e2100335. Nonacus products: Oncology Purpose: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, with more than 40% of patients initially diagnosed with multinodular HCCs. Although circulating cell-free DNA…
Read MoreDevelopment of methylation-based biomarkers for breast cancer detection by model training and validation in synthetic cell-free DNA | de Procé SM, et al | bioRxiv | Feb. 2022
de Procé SM, Adamowicz M, Dutta P, Warlow SJ, Moss J, Shemer R, et al. Development of methylation-based biomarkers for breast cancer detection by model training and validation in synthetic cell-free DNA. bioRxiv. 2022;2022-02. Nonacus products: Oncology Abstract Circulating tumour-derived DNA (ctDNA) carries the genetic and epigenetic characteristics of the tumour from which it is…
Read MoreDroplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients | Izquierdo E, et al | Neuro-oncology advances | Jan. 2021
Izquierdo E, Proszek P, Pericoli G, Temelso S, Clarke M, Carvalho DM, Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients. Neuro-oncology advances. 2021;3(1):vdab013. Nonacus Products: Germline Background: The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas…
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