Clinical Research (RUO) Products
For Research Use Only. Not for use in diagnostic procedures.
Targeted NGS panels designed to deliver ultrasensitive sequencing to support the study of genetic alterations in cancer samples, including liquid biopsies.
Our NGS library preparation and enrichment chemistry enables researchers to study cancer genomics and support the detection of mutations down to 0.1% VAF, opening up the possibility to study circulating tumor DNA (ctDNA) as well as genomic DNA (gDNA) with high analytical sensitivity.
Sample collection
cfDNA collection tubes (RUO)
The introduction of non-invasive approaches such as liquid biopsy, which utilise cfDNA has driven increased interest in cancer research and translational genomics. DNA obtained from whole blood can provide valuable genomic information for molecular analysis without the need for tissue biopsies.
Sample isolation
cfDNA bead-based extraction kit
Extracting cfDNA from biological samples can be challenging due to its low concentration and small fragment size. It is critical to minimise genomic DNA (gDNA) contamination from white blood cells, to enable reliable downstream analysis. Therefore, a cfDNA isolation method that is highly efficient at recovering smaller fragment sizes is highly desirable.
cfDNA spin column extraction kit (RUO)
The utility of cfDNA in research has increased dramatically since its discovery. These short fragment sizes of ~160 bp are typically found in low quantities of 1-100 ng/ml in plasma. It is therefore critical that sufficient good quality cfDNA is extracted from biological samples for downstream applications like NGS and qPCR.
Targeted panels
GALEAS™ Bladder (RUO)
GALEAS Bladder is an NGS enrichment panel with variant calling software for studying molecular markers in 23 genes associated with bladder cancer.
Designed to be used with gDNA extracted from the cell pellet in urine samples, it offers a non-invasive solution for research studies looking into the cancer genomics of bladder cancer. It is not intended for diagnostic or clinical decision-making purposes.
GALEAS™ Tumor (RUO)
An NGS panel designed in parallel with variant calling software for comprehensive genomic profiling of solid tumours.
GALEAS Tumor covers key DNA biomarkers across 519 genes streamlining the detection of SNVs, INDELs, CNVs, TMB, MSI and HRD into a single workflow for research laboratories. Cloud-based bioinformatic pipelines enable rapid integration into any laboratory. It is not intended for diagnostic or clinical decision-making purposes.
GALEAS™ HereditaryPlus (RUO)
A comprehensive research panel with tailored bioinformatics for studying genes associated with hereditary cancer.
Expertly curated design with coverage of 146 genes with known associations in inherited cancer, GALEAS HereditaryPlus includes major genes from the UK National Genomics Test Directory for research reference purposes. It is not intended for diagnostic or clinical decision-making purposes.
GALEAS™ uPCR: ESR1 (RUO)
An ultrasensitive qPCR assay designed to detect 11 ESR1 variants in cell-free DNA samples.
Simple to use and requiring only standard qPCR cyclers, this assay can be deployed in almost any molecular laboratory. It is not intended for diagnostic or clinical decision-making purposes.
Whole Exome
Nexome (RUO)
Nexome streamlines the diagnostic process by eliminating the need for multiple tests like chromosomal microarrays (CMA), Multiplex ligation-dependent probe amplification (MLPA), and Fluorescence in situ hybridization (FISH).
Whole Exome (RUO)
Optimize your sequencing efficiency with our Cell3™ Target: Whole Exome Enrichment panel.
By capturing 33 Mb of highly-conserved protein-coding regions and 99% of ClinVar variants, you can focus on the most relevant genomic content while reducing sequencing costs.
Custom panels
Panel design tool
At Nonacus we have developed an intuitive, online Panel Design Tool that puts your NGS panel design firmly in your hands, allowing you to create a custom panel in minutes.
Custom Panels
Customise your NGS oncology panel with the ultra-sensitive Cell3™ Target enrichment system. Convert cfDNA, gDNA, or FFPE DNA into libraries for NGS.
Our error suppression technology enables researchers to study cancer genomics and support the detection of mutations down to 0.1% VAF making it ideal for rare variant detection in liquid and tissue biopsies.
