Cell3 target

Detecting copy number variants using Next Generation Sequencing

By Victoria Simms / June 30, 2023 / Comments Off on Detecting copy number variants using Next Generation Sequencing

By Victoria Simms on June 29, 2023 Copy number variants can have big consequences on our health – so detecting them reliably and robustly is important – is NGS up to the job? Copy number variants (CNVs) are responsible for 5-10% of genetic disease – that’s why detecting them reliably and robustly is so important…

Read More

What is targeted next generation sequencing?

By nonacus-developer / March 31, 2023 / Comments Off on What is targeted next generation sequencing?

March 31, 2023 And why is it used for liquid biopsy samples? Targeted next generation sequencing (NGS) focuses sequencing efforts on specific subsets of the genome. By focusing only on regions of interest (ROIs) such as certain genes, hotspots or coding regions, it is possible to achieve greater coverage and improved sensitivity of variant calling.…

Read More

5 Tips for using the Nonacus Panel Design Tool

By Victoria Simms / December 20, 2022 / Comments Off on 5 Tips for using the Nonacus Panel Design Tool

By Victoria Simms on December 20, 2022 Get great coverage for the genes you care about Do you need to create a custom NGS panel? Read our tips to find out how to create and optimise your panel design At Nonacus, we have developed an intuitive, online Panel Design Tool that allows you to create custom…

Read More

Unique molecular identifiers: the key to unmasking real low frequency variants

By nonacus-developer / January 28, 2022 / Comments Off on Unique molecular identifiers: the key to unmasking real low frequency variants

January 28, 2022 How molecular barcodes help remove the PCR and sequencing errors that can mask important low-frequency variations in the analysis of cell-free DNA. Next Generation Sequencing (NGS) technologies are powerful tools that have accelerated the rate of life science research for the last decade. This is especially true in the areas of oncology…

Read More

Tumour Mutational Burden (TMB) and Microsatellite Instability (MSI) as markers for immunotherapy response

By nonacus-developer / December 22, 2021 / Comments Off on Tumour Mutational Burden (TMB) and Microsatellite Instability (MSI) as markers for immunotherapy response

Published December 22, 2021 | Reviewed by Victoria Simms on April, 22, 2024 The promise of Immune-checkpoint inhibitor therapies Immune-checkpoint inhibitor (ICI) therapies have heralded promise of a superior drug response and significantly increased survival for a small proportion of cancer patients across a range of cancers. Their success lies in the inhibition of biological mechanisms that prevent immune cells from attacking other cells. The challenge for immuno-oncology is to identify…

Read More

Nonacus Cell3™ Target technology assists with DNA methylation sequencing

By nonacus-developer / November 11, 2021 / Comments Off on Nonacus Cell3™ Target technology assists with DNA methylation sequencing

November 11, 2021 Researchers at The Centre For Genomic and Experimental Medicine, University of Edinburgh, have used Nonacus Cell3™ Target technology to undertake targeted DNA methylation sequencing with the aim of finding DNA methylation specific breast cancer markers. This work is funded by Cancer Research UK. Nonacus spoke to Dr. Martyna Adamowicz from the Centre for…

Read More

A less invasive, more comprehensive test for diagnosis of Coeliac Disease

By nonacus-developer / August 25, 2021 / Comments Off on A less invasive, more comprehensive test for diagnosis of Coeliac Disease

August 25, 2021 Coeliac Disease: developing a less invasive test for diagnosis Using immune repertoire profiling to test for coeliac disease Coeliac Disease is a chronic immune disorder whereby the body’s own immune system mistakenly attacks healthy tissue when triggered by gluten ingestion. This damages the surface of the small bowel (intestines), disrupting the body’s…

Read More

No Gluten Required

By nonacus-developer / May 27, 2020 / Comments Off on No Gluten Required

May 27, 2020. Reviewed by Victoria Simms, April 22, 2024 Coeliac disease is a serious, autoimmune disease of the gut caused by a reaction to eating gluten. It causes damage to the lining of the gut and means that the body can’t properly absorb nutrients from food. It affects 1 in 100 people in Europe…

Read More