Cell3 target
Detecting copy number variants using Next Generation Sequencing
By Victoria Simms on June 29, 2023 Copy number variants can have big consequences on our health – so detecting them reliably and robustly is important – is NGS up to the job? Copy number variants (CNVs) are responsible for 5-10% of genetic disease – that’s why detecting them reliably and robustly is so important…
Read MoreWhat is targeted next generation sequencing?
Written by Victoria Simms March 31, 2023. reviewed by Celina Whalley April 29, 2024 And why is it used for liquid biopsy samples? Targeted next generation sequencing (NGS) focuses sequencing efforts on specific subsets of the genome. By focusing only on regions of interest (ROIs) such as certain genes, hotspots or coding regions, it is…
Read More5 Tips for using the Nonacus Panel Design Tool
By Victoria Simms on December 20, 2022. Reviewed by Celina Whalley, April 26, 2024 Get great coverage for the genes you care about Do you need to create a custom NGS panel? Read our tips to find out how to create and optimise your panel design At Nonacus, we have developed an intuitive, online Panel…
Read MoreUnique molecular identifiers: the key to unmasking real low frequency variants
Written by Victoria Simms, January 28, 2022. Reviewed by Celina Whalley. April 26, 2024 How molecular barcodes help remove the PCR and sequencing errors that can mask important low-frequency variations in the analysis of cell-free DNA. Next Generation Sequencing (NGS) technologies are powerful tools that have accelerated the rate of life science research for the…
Read MoreTumour Mutational Burden (TMB) and Microsatellite Instability (MSI) as markers for immunotherapy response
Published December 22, 2021 | Reviewed by Victoria Simms on April, 22, 2024 The promise of Immune-checkpoint inhibitor therapies Immune-checkpoint inhibitor (ICI) therapies have heralded promise of a superior drug response and significantly increased survival for a small proportion of cancer patients across a range of cancers. Their success lies in the inhibition of biological mechanisms that prevent immune cells from attacking other cells. The challenge for immuno-oncology is to identify…
Read MoreNonacus Cell3™ Target technology assists with DNA methylation sequencing
November 11, 2021. Reviewed by Celina Whalley, April 26, 2024. Researchers at The Centre For Genomic and Experimental Medicine, University of Edinburgh, have used Nonacus Cell3 Target technology to undertake targeted DNA methylation sequencing with the aim of finding DNA methylation specific breast cancer markers.1 This work is funded by Cancer Research UK. Nonacus spoke…
Read MoreA less invasive, more comprehensive test for diagnosis of Coeliac Disease
August 25, 2021. Reviewed by Victoria Simms, April 23, 2024. Coeliac Disease: developing a less invasive test for diagnosis Using immune repertoire profiling to test for coeliac disease Coeliac Disease is a chronic immune disorder whereby the body’s own immune system mistakenly attacks healthy tissue when triggered by gluten ingestion. This damages the surface of the small…
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