Oncology

Remove The Need For Luck When Detecting Low Frequency Variants

Developing innovative technologies which enable early detection, treatment selection and patient monitoring through confident detection of even the lowest frequency variants.

Summary

Cell Free DNA (cfDNA) when extracted is typically of low quantity and the circulating tumor DNA, (ctDNA, tumor derived fraction) is an even smaller fraction of the total cfDNA. Additionally tumor mutations can occur as clonal mutations in all ctDNA or commonly due to tumor heterogeneity as sub-clonal mutations whereby only a small fraction of the ctDNA harbours a given mutation. Therefore exquisitely sensitive tools are required to find these mutations and measure them accurately, this is analogous to finding a 4 leaf clover in a field of clover.

Our Products

See our range of Oncology cfDNA products below.

Cell3™ Target

How Low Can You Go?

Detecting cancer early or monitoring cancer post chemotherapy or surgery requires extremely sensitive analysis due to the small amounts of cfDNA and low fraction of ctDNA content. The Cell3™ Target, targeted NGS kit incorporates error suppression technology including unique molecular indexes (UMI’s) and unique dual indexes (UDI’s) for removal of both PCR / sequencing errors and index hopping events. This allows confident and sensitive calling of mutations down to 0.1% VAF and from as little as 10ng ctDNA input.

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