Remove The Need For Luck When Detecting Low Frequency Variants
Developing innovative technologies which enable early detection, treatment selection and patient monitoring through confident detection of even the lowest frequency variants.
Cell Free DNA (cfDNA) when extracted is typically of low quantity and the circulating tumor DNA, (ctDNA, tumor derived fraction) is an even smaller fraction of the total cfDNA. Additionally tumor mutations can occur as clonal mutations in all ctDNA or commonly due to tumor heterogeneity as sub-clonal mutations whereby only a small fraction of the ctDNA harbours a given mutation. Therefore exquisitely sensitive tools are required to find these mutations and measure them accurately, this is analogous to finding a 4 leaf clover in a field of clover.