Sample collection and isolation cfDNA Collection Tubes
Cell3_Preserver_200ul_tube_in_hand_v2

Specialized cell-free DNA blood collection tubes

Cell3™ Preserver

Blood collection tubes for collection of whole blood and stabilization of cell-free DNA for up to 10 days.

The importance of blood collection methods in cell-free DNA applications

The introduction of non-invasive methods like liquid biopsy that use cell-free DNA (cfDNA) for molecular diagnostics has been of growing interest in oncology. DNA from whole blood can provide valuable genomic information for healthcare professionals without the need for tissue biopsies.

Whilst taking a blood sample is a simple procedure, if blood plasma is not preserved or isolated within 24 hours of blood draw, the degradation of nucleated white blood cells will cause the release of intracellular genomic DNA (gDNA) into the plasma. This can contaminate the cfDNA fraction affecting the reliability and validity of data. This time constraint means that any delays in transport of samples from collection site to analysis location can negatively impact on results.

The Cell3 Preserver blood collection tubes are an easy-to-use, direct-draw blood collection method that maintain white blood cell integrity for up to 10 days. They provide an alternative to EDTA tubes that help ensure collection of contamination-free cfDNA.

Key Features

  • Stabilizes whole blood for up to 10 days post blood draw for batching samples for countrywide or international shipping.
  • Preserves high quality cell-free DNA for use in downstream applications, such as qPCR and NGS.
  • Plastic tubes, compatible with standard draw equipment, reduce the chance of glass breakage during transport or centrifugation.
  • Barcoded labels allow seamless integration with your existing automation and laboratory management systems.
  • Ready to use directly from the box (no plastic wrapping)
Cell3_Preserver_50_tube_box

Maximize cfDNA yield

Figure 1. Sample stability: Yield

Stability of cfDNA yield [ng per 1ml of plasma]. Sample stability was evaluated using 3 different donors across 10 days, where total yields were shown consistent between the time points.

Figure 2. Yield: Cell3™ Preserver vs Market leader

cfDNA yield [ng per 1ml of plasma] for Cell3™ Preserver tubes compared to Competitor S, 10 days post blood draw.

Minimise gDNA contamination

Figure 1. % cfDNA: Cell3™ Preserver over 10 days

Whole blood cell stability and cfDNA integrity was evaluated from 3 different donors over 10 days, %cfDNA was measured for each time point.

FIgure 2: %cfDNA: Cell3™ Preserver vs Market leader

Percentage of cfDNA was measured 10 days after blood draw from the same 3 donors.

Figure 3. Electropherogram profile of cfDNA

cfDNA was extracted* from plasma separated after 10 days. Trace was generated with the TapeStation 4200, cfDNA assay. The electropherogram shows the distinct profile typical for good quality cfDNA samples. Sample cfDNA calculated by TapeStation software is 93%

*cfDNA extracted with Cell3 Xtract

Barcode scanner for CEll3 Preserver tubes

Designed to support streamlined workflows

The Cell3 Preserver blood collection tube has been designed for sample collection and shipment from around the world helping centralized lab facilities streamline their workflows.

Plastic tubes reduce the chance of tube breakage during transportation and centrifugation.

A sample barcode is included to allow LIMS compatibility, sample tracking and to assist high throughput clinical and translational labs.

Suitable for batching and transporting samples

Cell3 Preserver has superior blood cell stability allowing blood samples to be stored for up to 10 days after blood draw at ambient temperatures before processing. This minimizes the adverse effects of time, storage, and transport conditions on sample integrity and cfDNA extraction yield and opens up the possibility of decentralized sample collection.

For Research Use Only. Not for use in diagnostic procedures. 

See our customer publications

FEATURESPECIFICATION
Tube size16 x 100 mm
StabilizationPre-draw, up to 12 months stored between 15-25ºC
Post draw, up to 10 days at temperatures between 15-25°C
DO NOT freeze Cell3 Preserver tubes
Draw volume10 ml
Label typePaper
Quantity10 or 50 tubes/box
Additive/concentrationAdditive 1.0ml

ProductCatalog No.
Cell3 Preserver: Whole Blood Stabilization Tubes (10 Tubes)PRE_C3P_WBS_10_v2
Cell3 Preserver: Whole Blood Stabilization Tubes (50 Tubes)PRE_C3P_WBS_50_v2

How long can I store a blood sample in the Cell3 Preserver tubes?

What is the shelf life of Cell3 Preserver tubes once they have been delivered?

Is it normal to see some condensation within the Cell3™ Preserver tube packaging?

Is it normal for the plasma to have a pink coloration when using the Cell3™ Preserver tubes?

Interested in our Cell3™ Preserver blood collection tubes?