Prenatal Healthcare
Prenatal genetic tests optimized and validated using plasma & cffDNA
A range of non-invasive prenatal DNA testing products to allow sensitive and accurate detection of
fetal-specific genetic conditions.
Non-invasive prenatal DNA tests
Prenatal DNA testing currently requires an amniocentesis or CVS. Both are invasive procedures that carry a level of risk to the fetus, however, the cell-free fetal DNA (cffDNA) released into maternal blood during pregnancy offers an alternative method of detecting fetal genotypes that is less invasive and poses no risk to the fetus - a simple blood test.
The detection of cffDNA from a maternal blood sample can be challenging, though as it is present in very low quantities and requires extremely sensitive and accurate assays. Nonacus have developed two proprietary technologies, Cell3™ Direct (direct from plasma real-time PCR) and Cell3™ Target (exquisitely sensitive targeted NGS libraries), to provide your laboratory with a range of products for all your prenatal DNA testing needs.
Our Prenatal DNA Testing Products
See our range of NIPD tests validated on plasma and cffDNA below.
Cell3™ Direct: Fetal RhD Genotyping
The first direct from plasma NIPD test for fetal RhD status
The first 'direct from plasma' non-invasive prenatal test for fetal Rhesus D (RhD) genotyping. With no cffDNA extraction required, Cell3™ Direct reduces costs and saves time in fetal Rhesus D diagnosis. Targeting sequences specific for exons 5, 7 and 10 of the RhD gene, this kit can distinguish between RhD positive, negative and Psi genotypes in cffDNA.
Cell3™ Target: Custom NGS panels
Ultra sensitive NGS panels for prenatal genetic testing
Target the genes and variants important to your research by creating your own NGS panel using our ultra-sensitive Cell3 Target enrichment system. Suitable for pre-and postnatal genetic testing using cell-free fetal (cff) DNA, these targeted panels require as little as 10 ng DNA input and allow detection of heterozygous mutations down to 0.1% VAF.
Other Products for Prenatal Healthcare
Validated on amniocentesis and CVS samples.
Cell3™ Target: Nexome
A clinically enhanced exome panel for detecting SNVs, indels and CNVs
An exome panel with enhanced coverage of clinically relevant regions that allows you to confidently call all variants (SNVs, indels and CNVs) in one clinical-grade assay increasing your diagnostic yield without increasing your sequencing costs.
Cell3™ Target: ExomeCG
No more arrays. Detect SNVs, indels and CNVs in a single test.
An exome enrichment augmented with baits to provide increased coverage of genes of clinical importance for both pre- and postnatal testing. Designed specifically for cytogenetic analysis this exome enrichment allows you to detect all variants (SNVs, indels and CNVs) in a single assay from as little as 10ng input.
Validated on amniocentesis and CVS samples without the need for any culturing. For singleton, duo or trio based analysis.