Prenatal Healthcare

Optimised & Validated Using Both Plasma & cfDNA

A range of non-invasive prenatal products to allow sensitive and accurate detection of
fetal specific genetic conditions.


Prenatal genetic testing currently requires an amniocentesis or CVS, both invasive procedures that carry a level of risk to the foetus. However, the cell-free foetal DNA (cffDNA) released into maternal blood during pregnancy, offers an alternative method of detecting foetal genotypes that is less invasive and poses no risk to the foetus.  A simple blood test.

The detection of cffDNA from a maternal blood sample can be challenging though as it is present in very low quantities and requires extremely sensitive and accurate assays to be confident in results. Nonacus have developed two proprietary technologies, Cell3™ Direct (direct from plasma real-time PCR) and Cell3™ Target (exquisitely sensitive targeted NGS libraries), to provide your laboratory with a range of products for all your prenatal testing needs.

Our Prenatal Products

See our range of prenatal products validated on plasma and cff DNA below.

Cell3™ Direct RhD

The First Direct From Plasma NIPD Test

The first direct from plasma non-invasive prenatal diagnosis kit for Fetal RhD Genotyping provides a quicker, more cost effective and validated assay. The Cell3™ Direct Fetal RhD Group Genotyping kit targets sequences specific for exons 5, 7 and 10 of the RhD gene and can distinguish between RhD positive, RhD negative and RhD PSI genotypes in cfDNA.


Cell3™ Direct Fetal Sex Determination Kit

Improving Patient Pathways

Utilizing circulating cell free fetal DNA (cffDNA), which can be detected in maternal plasma from early in gestation, and through the use of our proprietary Cell3™ amplification technology the Cell3™ Direct Fetal Sex Determination kit accurately reports fetal sex early in pregnancy without the need for invasive procedures.

Cell3™ Target: Custom Design

Ultra sensitive analysis for prenatal genetics

Targeted NGS library capture that uses error suppression technology to remove PCR bias and error allowing detection of heterozygous mutations down to 0.1% VAF. Working with as little as 10ng input, this library capture kit provides the extremely sensitive analysis required for pre and postnatal genetic testing using cff DNA. And it offers you complete design flexibility.


Other Products for Prenatal Healthcare

Validated on amniocentesis and CVS samples. 

Exome sequencing for cytogeneticists

Cell3™ Target: ExomeCG

No more arrays. Detect SNVs, indels and CNVs in a single test.

An exome enrichment augmented with baits to provide increased coverage of genes of clinical importance for both pre- and postnatal testing. Designed specifically for cytogenetic analysis this exome enrichment allows you to detect all variants (SNVs, indels and CNVs) in a single assay from as little as 10ng input.

Validated on amniocentesis and CVS samples without the need for any culturing. For singleton, duo or trio based analysis.

Are you ready to innovate your cfDNA capability?

Contact us for a quote.