Prenatal Genetic tests optimised and validated using plasma & cffDNA
A range of non-invasive prenatal products to allow sensitive and accurate detection of
fetal specific genetic conditions.
Non-invasive prenatal healthcare
Prenatal genetic testing currently requires an amniocentesis or CVS, both invasive procedures that carry a level of risk to the foetus. However, the cell-free foetal DNA (cffDNA) released into maternal blood during pregnancy, offers an alternative method of detecting foetal genotypes that is less invasive and poses no risk to the foetus. A simple blood test.
The detection of cffDNA from a maternal blood sample can be challenging though as it is present in very low quantities and requires extremely sensitive and accurate assays to be confident in results. Nonacus have developed two proprietary technologies, Cell3™ Direct (direct from plasma real-time PCR) and Cell3™ Target (exquisitely sensitive targeted NGS libraries), to provide your laboratory with a range of products for all your prenatal testing needs.
Our Prenatal Products
See our range of prenatal products validated on plasma and cff DNA below.
Cell3™ Direct: Fetal RhD Genotyping
The first direct from plasma NIPD test for fetal RhD status
The first direct from plasma non-invasive prenatal diagnosis kit for fetal Rhesus D (RhD) genotyping provides a quicker, more cost effective and validated assay. The Cell3™ Direct Fetal RhD Group Genotyping kit targets sequences specific for exons 5, 7 and 10 of the RhD gene and can distinguish between RhD positive, RhD negative and RhD Psi genotypes in cffDNA.
Cell3™ Target: Custom NGS panels
Ultra sensitive NGS panels for prenatal genetics
Custom designed NGS panels that provide the extremely sensitive analysis required for pre-and postnatal genetic testing using cell-free foetal (cff) DNA. These targeted panels require as little as 10 ng DNA input and use error suppression technology to remove PCR bias and error allowing detection of heterozygous mutations down to 0.1% VAF.
Other Products for Prenatal Healthcare
Validated on amniocentesis and CVS samples.
Cell3™ Target: ExomeCG
No more arrays. Detect SNVs, indels and CNVs in a single test.
An exome enrichment augmented with baits to provide increased coverage of genes of clinical importance for both pre- and postnatal testing. Designed specifically for cytogenetic analysis this exome enrichment allows you to detect all variants (SNVs, indels and CNVs) in a single assay from as little as 10ng input.
Validated on amniocentesis and CVS samples without the need for any culturing. For singleton, duo or trio based analysis.