Sample preparation: Sample collection and isolation

In genomic medicine, proper sample preparation is crucial for obtaining accurate and meaningful results, especially when working with low-abundance cell-free DNA (cfDNA) that is susceptible to contamination by genomic DNA (gDNA).

At Nonacus, we recognize the significance of optimising the sample preparation process to maximize the yield, purity, and quality of cfDNA. Our specialized solutions, including the Cell3™ Preserver for whole blood collection, and the Cell3 Xtract kit and Bead Xtract kit for cfDNA extraction, have been meticulously designed to overcome these challenges.

By utilizing our collection tubes and advanced sample preparation kits, you can enhance the sensitivity and accuracy of subsequent genetic analyses, unlocking the full potential of cfDNA for precise and insightful genomic analysis.

Collection

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Cell-free DNA collection tubes

These specialized blood collection tubes are an easy-to-use, direct-draw blood collection method that maintain white blood cell integrity for up to 10 days. Using a proprietary preserver, they provide an alternative to EDTA tubes that help ensure collection of contamination-free cfDNA.

Made from plastic to reduce the chance of breakage during transportation and centrifugation, they have been designed for sample collection and shipment from around the world helping centralized lab facilities streamline their workflows.

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Isolation

Close up of the automated bead-based cfDNA extraction kit

Automatable bead-based cfDNA extraction kit

Maximize your cfDNA yield with the Bead Xtract cfDNA NGS kit. Utilizing high-binding capacity paramagnetic particles, it offers input volume flexibility (0.5-10 ml) and supports manual and automated protocols.

Achieve efficient, scalable extraction in just 30 minutes of setup time.

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Spin column-based cfDNA extraction kit

Streamline your cfDNA extraction with the Cell3 Xtract NGS kit.

This robust and efficient solution isolates cfDNA from plasma and other samples, eliminating the need for specialized equipment. Process up to 10 ml within 90 minutes and enhance your cfDNA recovery and concentration.

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Resources

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Publications

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Protocols

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Panel Design Tool

Are you ready to unleash your cell-free DNA sample potential?

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