Oncology GALEAS™ Bladder
GALEAS Bladder Hybridization and Capture Kit

NGS-based urine bladder cancer test

GALEAS Bladder

A non-invasive, sample to report, molecular triage test for bladder cancer. It leverages ultra-sensitive, targeted next generation sequencing (NGS) chemistry to interrogate somatic mutations in 23 genes associated with bladder cancer in tumor-derived genomic DNA extracted from a urine sample. It offers a viable alternative to flexible cystoscopy.

One test for ALL stages of bladder cancer

Delivers sensitivity and specificity equivalent to cystoscopy for both Non-Muscle Invasive Bladder Cancer (NMIBC) and Muscle Invasive Bladder Cancer (MIBC).

Automated and scalable workflow

GALEAS Bladder can be run in any NGS capable laboratory and automated and scaled according to throughput.

Sample to answer solution

From home sample collection through to bioinformatics and reporting, the process is optimized and streamlined to maximize efficiencies.

Part of a suite of products for oncology and liquid biopsy

GALEAS Bladder workflow

GALEAS Urine Collection Device

Service laboratory dispatches bar coded GALEAS urine collection device to patient

gDNA Extraction

Returned urine sample is centrifuged and gDNA extracted from cell pellet using Bead Xtract urine gDNA extraction kit

Sequencing Machine

NGS libraries are prepared with the GALEAS Bladder kit and sequenced. 5M reads (2 x 150bp PE reads)

Computer Screen with GALEAS Software

FASTQ files are uploaded to secure cloud-based GALEAS analysis platform

Report

Results are analyzed, report generated and shared directly with requesting physician

GALEAS Urine Collection Device

Shipped ready for dispatch to patients, the simple, intuitive cardboard collection device allows patients to provide a urine sample in the comfort of their own home.

The sample is returned to the lab in a 50 ml Falcon tube containing our proprietary preserver validated with our DNA extraction kit and panels to ensure optimal performance.

The tube is barcoded to provide full traceability.

GALEAS Bladder enables the highly sensitive and accurate detection of tumor-derived DNA across all stages and grades of bladder cancer

Sensitivity Specificity
pTa 86% 86%
T1 95% 86%
T2+ 89% 86%
G1 76% 86%
G2 92% 86%
G3 92% 86%
NMIBC 89% 86%
MIBC 89% 86%
GALEAS Bladder sensitivity compared to cystoscopy and cytology

Figure 1: GALEAS Bladder performance across all stages of bladder cancer and compared to reported sensitivity of cytology and cystoscopy.

Why choose GALEAS Bladder?

Simple end to end workflow for easy implementation

From ready to ship urine collection devices through to secure cloud-based reporting the process is optimized to maximize efficiencies.

Optimized reagents ensure reliability of test results

All reagents associated with the GALEAS Bladder workflow have been developed and optimized to ensure consistent and reliable results.

Flexible throughput offers scalability

By covering a wide range of markers, GALEAS Bladder can be used for patient monitoring, relapse, MRD surveillance and companion diagnostics as well as hematuria triage.

Find out more about the research behind the development of GALEAS Bladder

References

Click here to see our customer publications

Product DescriptionCatalog No.
GALEAS Urine Collection DeviceNGS_GAL_UCD
GALEAS Bead Xtract: Urine gDNA Extraction KitPRE_GAL_BXG_96
GALEAS Bladder Kit A - includes 1-96 indexes and complimentary analysis of FASTQ files using GALEAS Analysis software for up to 96 samplesNGS_GAL_BCP_FR_96_A
GALEAS Bladder Kit B - includes 1-96 indexes and complimentary analysis of FASTQ files using GALEAS Analysis software for up to 96 samplesNGS_GAL_BCP_FR_96_B
GALEAS Bladder Kit C - includes 1-96 indexes and complimentary analysis of FASTQ files using GALEAS Analysis software for up to 96 samplesNGS_GAL_BCP_FR_96_C
GALEAS Bladder Kit D - includes 1-96 indexes and complimentary analysis of FASTQ files using GALEAS Analysis software for up to 96 samplesNGS_GAL_BCP_FR_96_D
GALEAS Bladder Validation Control KitNGS_GAL_GBVC_48

Interested in GALEAS Bladder?